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The first race was run in Dallas, Texas in 1983, with 800 participants.

The primary source of revenue for the event is donations collected by the participants in the race.

Since 1992, Komen has also annually awarded work in the field of cancer research with the Komen Brinker Award for Scientific Distinction.

In recent years, Komen has cut by nearly half the proportion of fund-raising dollars it spends on research grants, according to a 2012 Reuters analysis.

Believing that no single approach to breast health will prove effective around the world, Komen works with local communities and organizations to develop programs for particular groups or cultures. Komen for the Cure announced their involvement with the US-Middle East Partnership for Breast Cancer Awareness and Research, a Middle East Partnership Initiative program that unites leading breast cancer advocates in the U. and the Middle East with the goal increasing early detection of breast cancer and reduce mortality through improved awareness, increased clinical resources, and research.

On October 28, 2010, Jerusalem held its first Susan G. Over 5,000 Christian, Muslim, and Jewish people walked and ran to show solidarity in what was described as an historic event.

Komen Breast Cancer Foundation, often referred to as simply Komen, is the largest and best-funded breast cancer organization in the United States.

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In 2012, Komen's controversial continued funding for mammogram referrals provided by Planned Parenthood caused a significant decline in donations, event participation and public trust, after an attempt to withdraw Planned Parenthood’s funding resulted in political pressure.Many scientific reviews have concluded that indiscriminate screening mammography for all middle-aged and older women, regardless of each woman's individual risk of developing breast cancer, results in overtreatment of some women whose cancer would never harm them.For every one woman whose life is saved by screening mammography, 250 to 500 women will be told that they might have breast cancer when they don't (false positives), 125 to 250 will have biopsies performed, and between two and ten women will receive unnecessary treatment.In 2011, Komen said that three-quarters of the net proceeds from the event were being used locally to pay for community outreach programs, breast health education, and breast cancer screening and treatment projects run by the Komen affiliate, and the remaining quarter was being sent to the central organization.Komen is a key entity in the controversy over pinkwashing.

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